ATG5 and hepatocellular carcinoma: However, another study found that in hepatoma cells resistant to Sorafenib, the downregulation of METTL3 led to the degradation of FOXO3 and the upregulation of autophagy proteins such as ATG5, ATG7, and ATG16L1, promoting autophagy-induced drug resistance of hepatocellular carcinoma cells to Sorafenib [34].