VHL and colorectal cancer: These samples typically originated from experiments where colorectal cancer cell lines were exposed to hypoxia for a short time (i.e., between 1 and 2 h in HCT116, HCT-15, LoVo, WiDr, and COLO-125), which might be too early to observe a marked transcriptional response to hypoxia, and experiments when VHL was reintroduced in hypoxia vs. VHL mutated in normoxia in 786-O cells, which could be expected as reintroduction of VHL might not completely recapitulate the hypoxia response.