Some important cytokines/chemokines associated with PC include VEGF, IL-6, IL-1, IL-7, CCL2, CXCL12, CXCL16, TGFβ, CXCL1, CXCL8, CX3CL1 and RANKL [77]. The gene discussed is IL1B; the disease is pachyonychia congenita.