ccfDNA concentrations did not correlate significantly with age, tumour diameter, ACTH, DHEAS, or ARR levels (Fig. 2A-C), but we observed a mild trend toward a positive correlation with cortisol levels after ONDST when considering all patients (n = 44, R = 0.292, P = 0.064, Fig. 2D). The gene discussed is POMC; the disease is neoplasm.