Our previous study has demonstrated that intracerebroventricular injection of Aβ25–35 peptide significantly increased CRMP2 phosphorylation at Ser522 in the CA1 region of WT mice [26] and in 18-month-old Tg2576 mice exhibiting amyloid pathology [27, 28]. The gene discussed is DPYSL2; the disease is amyloidosis.