Several authors reported that sustained IL-1β overexpression decreases Aβ-induced pathology by regulating the degradation of microglial-dependent plaque or enhancing the cleavage of non-amyloidogenic APP in a mouse AD and a cell culture model (Shaftel et al. 2007; Tachida et al. 2008; Ghosh et al. 2013). The gene discussed is IL1B; the disease is Alzheimer disease.