Increased plasma levels of IL-1β, IL-1Ra, IL-33, IL-18BP, and soluble receptors sIL-1R1, sIL-1R3, and sIL-1R4 have been recorded in patients with AD (Italiani et al. 2018) suggesting that systemic chronic inflammation is associated with AD pathogenesis. Here, IL18BP is linked to Alzheimer disease.