IL18 and Alzheimer disease: This was confirmed by the increase in IL-18 levels in AD brains (Ojala et al. 2009), and diseases that increase AD risk, as T2DM (Aso et al. 2003), ischemic heart disease (Mallat et al. 2001), obesity (Esposito et al. 2002) and cognitive impairment (Bossù et al. 2010).