Alves et al. (2017) reported that elevated IL-2 in the hippocampus of APP/PS1ΔE9 mice treated with IL-2 increased Treg activation and improved AD pathology suggesting that the retrieval of memory impairment in these animals was mediated by IL-2-induced tissue remodeling, increased synaptic plasticity and recovery of spine density. Here, IL2 is linked to Alzheimer disease.