Supporting the role of IL-1 in AD, IL-1 signaling inhibition in transgenic AD mice by IL-1R knockout was found to reduce the burden of Aβ (Williamson et al. 2011) and this protective impact was believed to depend on decreased AD-related neuroinflammation (Barrientos et al. 2012). The gene discussed is IL1R1; the disease is Alzheimer disease.