CASP1 and Alzheimer disease: They suggested that up-regulation of IL-18 expression can cause an adverse inflammatory vicious cycle in which IL-18 induces the formation of IL-1β and IFN-γ, the latter cleaving inactive IL-1β and IL-18 to produce their mature active forms by caspase-1, thus enhancing IL-18 expression which participates in the pathogenesis of AD.