According to the article, HERC1 deficiency leads to imbalanced bone homeostasis, causing osteopenia, with distinct effects in young female mice.15 The observed features in previously reported affected individuals, such as macrocephaly, dysmorphic facies, prominent forehead, long fingers, and vertebral column abnormalities, may be attributed to altered bone homeostasis.15 Here, HERC1 is linked to Osteopenia.