The MHC-IhiGal9+ CAFs are inversely related to the presence of a TCF1+GZMK+ subset of CD8+ T cells, and Gal9 on CAFs induce CD8+ T-cell dysfunction and decrease tumor-infiltrating TCF1+CD8+ T cells in the TME of HNSCC [14]. The gene discussed is CD8A; the disease is head and neck squamous cell carcinoma.