VEGFA and diabetes mellitus: They proposed two explanations for this correlation: first, that outer retinal ischemia may result from disruption in choroidal blood flow, potentially leading to increased vascular endothelial growth factor expression and DR progression [32, 33]; and second, that capillary dropout in the inner choroid might result from diabetes-induced damage to the RPE and subsequent disturbance in choriocapillaris maintenance [32, 34].