Examples of replicated gene-environment interactions include BRCA-1 associated protein-1 (BAP1) mutations and asbestos exposure for mesothelioma [127], chromodomain helicase DNA-binding protein 8 (CHD8) and pesticide exposure for autism spectrum disorder [128], the fat mass and obesity-associated gene (FTO) and physical activity for obesity, and dopamine receptor D4 (DRD4) and parenting style for attention-deficit/hyperactivity disorder (ADHD) [129]. The gene discussed is CHD8; the disease is obesity due to melanocortin 4 receptor deficiency.