Consistently, RT-qPCR assays confirmed that silencing MAZ significantly reduced LRP11 expression in HCC cells (Fig. 4F), whereas knockdown of YY1 and VDR had no discernible effect on LRP11 mRNA levels (Fig. S2E-F), highlighting MAZ as the key regulator of LRP11 expression. The gene discussed is MAZ; the disease is hepatocellular carcinoma.