To evaluate the effects of LRP11 on HCC in vivo, we established subcutaneous xenograft and lung metastasis models using Huh7 and Hep3B cells stably transfected with either LRP11 knockdown (sh-LRP11#1, sh-LRP11#2), overexpression (LRP11-OE), or control constructs (Fig. 5A). This evidence concerns the gene LRP11 and hepatocellular carcinoma.