IL6 and neoplasm: The main cellular source of IL-6 are monocytes, T cells, epithelial cells, tumor cells and tumor-associated fibroblasts (Masjedi et al. 2018; Unver and McAllister 2018), which participate in regulating acute phase reactions, activating T helper (Th) cells, inhibiting T regulatory (Tregs) cells, and differentiating B cells (Scheller et al. 2011).