STAT3 and Sepsis: CS and IL-6 related signaling pathways transduction are considered as crucial factors involved in sepsis, such as upregulation of IL-6/JAK/STAT3 signaling promotes the progression of sepsis (An et al. 2023), involvement of IL-6 signaling pathway in the pathogenesis of MOF (Kang and Kishimoto 2021) and other hyperinflammatory diseases (Cron et al. 2023).