IL-6 induced muscle atrophy of mice (Zanders et al. 2022) and acute lung injury (ALI) in sepsis through JAK-STAT signaling pathway (Chang et al. 2019; Wang et al. 2022a; Zhang et al., 2023b), and IL-6 was the favorable target for sepsis inflammation (Pearce et al. 2020). The gene discussed is IL6; the disease is acute respiratory distress syndrome.