A case report of intellectual disability (ID) showed that neuroligin 4 X-linked (NLGN4X, Gene ID: 57502), histone deacetylase 8 (HDAC8, Gene ID: 55869), TATA-box binding protein associated factor 1 (TAF1, Gene ID: 6872), and USP9X genes were associated with XCI escape. This evidence concerns the gene HDAC8 and Intellectual disability.