ADIPOQ and type 2 diabetes mellitus: One possible clarification of our findings is that this silent mutation, a synonymous mutation in exon 2 near the exon-intron junction, does not modify the amino acids sequence (GGT→GGG, Glycine→Glycine), and might impact adiponectin gene expression and circulating concentration of adiponectin via its linkage disequilibrium with another polymorphism in one of the introns that causes destabilization of the pre-mRNA, results in declined mRNA levels, and finally the development of pathophysiological effect and elevating phenotypic variability (DPN risk in T2DM patients)37,46.