ADIPOQ and type 2 diabetes mellitus: They speculated that although T2DM is characterized by “suppressed” adiponectin synthesis as reflected by lower adiponectin levels in T2DM patients in comparison to controls, diabetic carriers of the + 276 TT allele might be able to overcome this suppressed state in the presence of chronic inflammation that represents a characteristic of T2DM and a stimulus for adiponectin synthesis causing sufficiently increase in adiponectin levels.