Hyperglycemia is an upregulation in the production of reactive oxygen species (ROS) with cytosolic NADPH oxidase and insufficiency in main antioxidants like reduced glutathione (GSH), which initially cause complications such as diabetic retinopathy (DR), diabetic nephropathy (DF), and diabetic neuropathy (DN)56–59. The gene discussed is FMO5; the disease is Hyperglycemia.