Infertility in Thra1PV/+ mice was driven by uterine pathology characterized by endometrial squamous metaplasia with transcriptional perturbations that included suppression of Krüppel-Like factor 9 (Klf9), a key transcriptional regulator for squamous differentiation24 and endometrial differentiation25,26. Here, KLF9 is linked to Infertility.