IL4 and intervertebral disk degenerative disorder: More specifically, Ge et al.13 has previously demonstrated that IL-10 could be used to delay IDD through its anti-inflammatory response by inhibiting p38 MAPK pathway activation12, while recently Kedong et al.11 has proposed that the recombinant IL-4 delivery into the IVD might have a beneficial therapeutic effect by reducing disc inflammation following herniation11.