CTRB1 and pachyonychia congenita: Similarly, the rs7190458 genetic variant near the BCAR1 scaffold protein, Cas family member (BCAR1) and chymotrypsinogen B1 (CTRB1) on chromosome 16 (Fig. 2B) showed a genome-wide significant association with PC versus benign pancreatic cysts (OR (95%CI) = 0.152 (0.094–0.244)).