After virus infection, Piezo1 channel activation was downregulated by GsMTx4 treatment, leading to reduced PAD4 expression, ROS production and NET formation in neutrophils, and TNFα and NOS2 expression was decreased in macrophages from the BALF and lung (Fig. 7A–F and Supplementary Fig. S16A-C). The gene discussed is PADI4; the disease is viral infectious disease.