WIF1 and neoplasm: Wnt inhibitory factor-1 (WIF1) is regarded as a significant molecule in the progression of OSF malignancy, and the promoter methylation of WIF1 is tumor-specific; it serves as a potential epigenetic biomarker for the OSF carcinogenesis.205 Other studies even confirmed noncoding RNAs such as LncADAMTS9-AS2206 and circEPSTI1207 were also involved in the process of OSF carcinogenesis.