CRTC1 and cancer: Mfsd8 was predicted to act upstream of TORC1 signaling and participate in cellular catabolic processes.73 Yi et al. demonstrated that hyperactive mutation of PI3K-AKT-mTOR signaling prevents cancer cells from ferroptosis via SREBP1/SCD1-mediated lipogenesis.74 However, to date, whether miR-143-3p acts as upstream of Mfsd8 is not clear.