IL13 and Alzheimer disease: However, when comparing the mRNA expression of both targets between the two groups, we found the following differences: Mast cells from AD patients showed a significantly higher 5-LO mRNA expression in non-stimulated cells (24,9-fold) and in cells stimulated with IL-4 (1,70-fold) or IL-13 (85,1-fold) than in cells from HVs.