On video-level comparisons across three key views (parasternal long-axis, parasternal short-axis, and apical-4-chamber), the view-agnostic model outperformed view-specific models (δ[AUROC] of 0·05 [95% CI 0·03–0·07] for hypertrophic cardiomyopathy and 0·03 [0·01–0·06] for transthyretin amyloid cardiomyopathy; appendix p 10). This evidence concerns the gene TTR and hypertrophic cardiomyopathy.