On a video-level analysis of the YNHHS emergency department POCUS cohort, the view-agnostic model reached higher discrimination compared with view-specific models for hypertrophic cardiomyopathy (δ[AUROC] of 0·03 [95% CI 0·00–0·06]) and transthyretin amyloid cardiomyopathy (0·15 [0·10–0·21]). Here, TTR is linked to cardiac amyloidosis.