Of note, the ability of the classifier to detect hypertrophic cardiomyopathy and transthyretin amyloid cardiomyopathy was independent of the presence of moderate or severe left ventricular hypertrophy (described in the official report of 89 [8·6%] studies with the respective probabilities reaching an AUROC curve of 0·68 [95% CI 0·57–0·67] and 0·61 [0·57–0·65] for discriminating moderate or severe left ventricular hypertrophy from mild or no left ventricular hypertrophy. The gene discussed is TTR; the disease is cardiac amyloidosis.