Our analysis showed that the model trained with NFASC and GDF15 had the superior performance in the prediction of advanced fibrosis, with about 93% and 87% balanced accuracies in the discovery and validation cohorts, respectively, compared to that trained by FIB-4 (79% and 62% balanced accuracies, respectively) (Figure 6E). The gene discussed is GDF15; the disease is fibrosis.