FOXC2 and digestive system neuroendocrine tumor, grade 1/2: Galvan et al reported that high expression of snail1 and Foxc2 was associated with invasion and metastatic spread in gastroenteropancreatic neuroendocrine tumors (GEP NETs) [6].Snail1 is known to be a regulatory factor of epithelial-mesenchymal transition (EMT), a biological process that enhances tumor cell migration.