AKT1 and radiation pneumonitis: According to Li et al, Radix Salviae Miltiorrhizae is likely a target of PTSG2 based on NP predictions, potentially playing a regulatory role in radiation pneumonia through the PI3K-AKT, HIF-1, and TNF signaling pathways, which is beneficial for multi-target resistance.[15]Houttuynia cordata Thumb (H. cordata; Saururaceae) involves 4 signaling pathways (PI3K-Akt, Jak-STAT, MAPK, and NF-κB).