SOX2 and familial pancreatic carcinoma: In some tumors, SOX2 expression is associated with increased Tregs, which might occur by regulating immunosuppressive cytokines.[104] In addition, SOX2 facilitates lung metastasis in breast cancer by recruiting TAMs.[17] Chen et al found that SOX9 is a key regulatory molecule that recruits tumor-associated macrophages and inhibits the expression of CD8+ T cells and promotes pancreatic cancer progression.[105]