For example, overexpression of SOX2 correlates with upregulation of programmed cell death ligand 1 (PD-L1) levels on tumor cell surfaces which promotes immune escape by tumor cells.[16] In addition, SOX2 has been found to enhance immune suppressive environment further assisting tumor cells to escape immune surveillance by potentiating recruitment and activation of regulatory T cells (Tregs).[17] This mini-review will overview the structure and function of SOX family, its roles in cancer immune evasion and potential targets for therapy. The gene discussed is SOX2; the disease is cancer.