The most important immunohistochemical markers that support the diagnosis of PPM are EMA (+) and Vimentin (+), and other markers such as CK, S-100 protein, and CD34 may be focally positive.[9] Intracranial meningiomas can also metastasize to the lungs, but it is inconclusive whether ectopic meningiomas can develop pulmonary metastases, so a thorough patient history should be taken before diagnosing a primary meningioma. The gene discussed is VIM; the disease is meningioma.