CTHRC1 and breast carcinoma: The results showed that CTHRC1 was associated with the infiltration of TAMs in breast cancer and that CTHRC1 may induce TAM recruitment and M2 polarization by regulating the PI3K/AKT signaling pathway.[59] Other researchers have shown that CTHRC1 expression is upregulated in EC tissues and that CTHRC1 expression is positively correlated with the number of infiltrating TAMs.