AKT1 and cancer: Additionally, Modified Jianpi Yangzheng decoction can directly induce apoptosis in gastric cancer cells by inhibiting the PI3K/AKT/mTOR signaling pathway and can also prevent TAMs from undergoing M2 polarization by decreasing the amount of PKM2 in tumor cell-derived exosomes, thus playing an antitumor role.[129] In recent years, nanoplatform-mediated chemotherapeutic drug delivery has facilitated the development of clinical cancer therapies.