Polarized M2 TAMs can activate the CXCL13/CXCR5/NF-KB/p65/miR-934 positive feedback loop in CRC cells by secreting CXCL13.[9] Nie and colleagues reported that the secretion of chemokine ligand 5 by malignant phyllodes tumors (PTs) was associated with a poor prognosis. This evidence concerns the gene NFKB1 and colorectal carcinoma.