Further studies revealed that miR-183-5p promotes CRC cell proliferation, invasion, and metastasis by targeting thioesterase superfamily member 4 to activate the PI3K/AKT and NF-kB pathways.[81] In addition, researchers have reported that miRNAs derived from M2 TAM-derived exosomes can both inhibit and promote tumor development. The gene discussed is NFKB1; the disease is colorectal carcinoma.