The results showed that CTHRC1 was associated with the infiltration of TAMs in breast cancer and that CTHRC1 may induce TAM recruitment and M2 polarization by regulating the PI3K/AKT signaling pathway.[59] Other researchers have shown that CTHRC1 expression is upregulated in EC tissues and that CTHRC1 expression is positively correlated with the number of infiltrating TAMs. This evidence concerns the gene AKT1 and breast cancer.