CXCL5 derived from M2 TAMs also act as a chemokine to induce peripheral mononuclear macrophages to enter the TME and promote the formation of a drug-resistant microenvironment in gastric cancer.[89] In CRC, researchers have shown that resistance to 5-FU is also achieved through crosstalk between M2 TAMs and tumor cells. Here, CXCL5 is linked to gastric cancer.