TGFB1 and hepatocellular carcinoma: Rheum palmatum is a naturally occurring anthraquinone extracted from rhubarb (Rheum palmatum L.)roots that has shown anticancer activity against a variety of cancers both in vivo and in vitro.[114,115] Yin and colleagues found that myricetin induces the transition of M2 TAMs to M1 TAMs via the miR-26a/TGF-β1/AKT axis, which inhibits the growth of HCC and exerts antitumor effects.[116] Myricetin, a natural compound isolated from sterile mycelia, inhibits sphingomyelin synthesis.