AKT1 and hepatocellular carcinoma: Autophagy is also a key regulatory process in TAMs that both regulates the stability of the intracellular environment and participates in the regulation of multiple specific immune functions.[63] Some researchers have shown that autophagy activation of TAMs in primary HCC promotes the M2 polarization of TAMs.[64] Further studies revealed that the autophagy of TAMs in HCC promotes both the M2 polarization of TAMs and the aggressive biological behavior of HCC cells, and that the AKT signaling pathway plays an important role in this process.