Increasing evidence suggests that TAM infiltration and recruitment play crucial roles in tumorigenesis and metastasis.[53–55] Researchers have shown that in breast, pancreatic and bladder cancers, increased infiltration of TAMs is positively correlated with tumor progression and poorer overall patient survival.[56,57] Researchers have shown that the AKT signaling pathway plays an important role in the infiltration and recruitment of TAMs. The gene discussed is AKT1; the disease is urinary bladder cancer.