HMGB2 and myocardial infarction: HMGB2 has been involved in various cellular processes, such as cell differentiation, DNA replication, repair, transcription, migration, and so on.[36] Previous studies have exhibited that HMGB2 was highly expressed in patients with myocardial infarction and positively correlated with the severity of myocardial infarction and cellular apoptosis.[37] Furthermore, Huang et al[38] found that downregulation of HMGB2 could reduce the infarct size, inflammatory responses, and apoptosis in cerebral injury.