NME5 and cancer: Upon comparison, we found that POLR2D, POLR2K, RRM2B, ABAT, POLR2B, NME3, POLR2F, ITPA, and UPRT were significantly upregulated in cancer tissues, whereas NT5C1A, POLR3GL, UPB1, and NME5 were significantly downregulated (Fig. 9B).