RRM2B and breast cancer: Studies have shown that DHODH is implicated in tumor growth, invasion, and resistance in various cancers, including BC.[22,23] In specific cancer contexts, elevated expression or mutation of NT5C1A may aid tumor cells in evading DNA damage induced by chemotherapy, pointing to its potential role in BC chemoresistance development.[24] RRM2B is indispensable for DNA replication and repair, contributing to DNA stability maintenance.