Upon comparison, we found that POLR2D, POLR2K, RRM2B, ABAT, POLR2B, NME3, POLR2F, ITPA, and UPRT were significantly upregulated in cancer tissues, whereas NT5C1A, POLR3GL, UPB1, and NME5 were significantly downregulated (Fig. 9B). The gene discussed is RRM2B; the disease is cancer.