For defining tumor-infiltrating lymphocytes (TILs), six CD8+ T cell subsets (CD8-01 to CD8-06) were identified, including proliferative (T.pro), exhausted (T.ex), effector (T.eff), residential memory (T.rm), and naïve (T.na), given their specific expression of Mki67, Pdcd1, Gzmb, Klrd1, Il2rb, and Tcf7 genes, respectively. This evidence concerns the gene TCF7 and neoplasm.