Further analysis demonstrated that EGFR was involved in many biological processes and pathways related to glioblastoma according to GeneCards Suite gene sharing, such as negative regulation of apoptotic process, positive regulation of ERK1 and ERK2 cascade, EGFR signaling pathway, ERBB2 signaling pathway, cellular response to drug and MAPK cascade in the top 10 biological processes and almost all the top 20 pathways (Fig 8A and 8B and S11 Table). The gene discussed is MAPK3; the disease is glioblastoma.