High and widely varying rates of GLP-1 RA discontinuation at 1 year have been reported, ranging from 37% to 81%.20,21,22,23,24 Multiple factors have been associated with discontinuation, including cost, insurance type, comorbidities, and absence of type 2 diabetes.22,23 The magnitude of weight loss (and its association with GLP-1 RA discontinuation) has largely been omitted from previous analyses. This evidence concerns the gene GLP1R and type 2 diabetes mellitus.