In this cohort study of 125 474 patients initiating GLP-1 RAs, 46.5% of patients with and 64.8% without type 2 diabetes discontinued within 1 year; 47.3% of patients with and 36.3% without type 2 diabetes subsequently reinitiated a GLP-1 RA within 1 year. This evidence concerns the gene GLP1R and type 2 diabetes mellitus.