Similarly to VEGFA, regarding HIF1A in endometrial tissue, a significant trend was observed with increasing grading but not in the case of EPAS1. However, we did not observe differences in the expression levels for either HIF1A or EPAS1. We also observed a significant correlation between both HIF1A and VEGFA expression levels and tumor grading but not in the case of EPAS1. It was estimated that HIF1A proteins positively correlated with poor prognosis in EC (Seeber et al. 2010), and it was also shown that VEGFA factors significantly differed between tumor grading (Dziobek et al. 2019). This evidence concerns the gene EPAS1 and neoplasm.