Currently, serum biomarkers such as cytokeratin 19 fragment (CYFRA21-1), pro-gastrin releasing peptide (ProGRP), carcinoembryonic antigen (CEA), neuron-specific enolase (NSE), and squamous cell carcinoma-associated antigen (SCCA) have shown potential clinical utility for diagnosing lung cancer [52]. The gene discussed is ENO2; the disease is lung cancer.