IRS2 and colorectal carcinoma: IRS2 serves as a crucial hub in insulin/IGF-1-signaling, regulating metabolic processes in cancer cells.8 Given the distinct conditions in the brain microenvironment compared to the colon and other metastatic sites, which include lower oxygen levels and reduced glucose availability,25 we postulated that IRS2 facilitates the metabolic adaptation of CRC cells to the brain.