MTOR and colorectal carcinoma: While the genomic alterations (GA) in primary CRC and liver or lung metastases are well understood, those driving CRC BM are not.5 Other cancers that metastasize to the brain, like lung, melanoma, and breast cancers, commonly show alterations in the PI3K/AKT/mTOR pathway.6 Therefore, we hypothesized that specific GA promote CRC BM.