Consistent with the regulation of FSP1, FTO, and ALKBH5, CRC cells expressing HDAC1K412R displayed higher enrichment of H3K27ac in the promoters of FTO and ALKBH5, along with lower m6A modification and mRNA stability of FSP1 mRNA (Figure 6G–I). This evidence concerns the gene AIFM2 and colorectal carcinoma.