Acanthopanax senticosus polysaccharides (ASPS) inhibited the NF‐κB/MLCK pathway, thereby improving intestinal epithelial dysfunction during endotoxemia.[47] Activated NF‐κB p65 translocates from the cytoplasm to the nucleus, binds to the MLCK promoter, and upregulates MLCK protein expression. The gene discussed is NFKB1; the disease is serum lipopolysaccharide activity.