CDKL5 and epilepsy syndrome: MeCP2 and CDKL5 play a coordinated role with Reelin‐dependent signalling in the laminar structure of neurons as well as in synaptic neurotransmission in the hippocampus [56, 57] Dysfunction of the gene encoding the secreted protein Reelin has been reported in patients with some epilepsy syndrome, such as autosomal dominant lateral temporal epilepsy [58].