This article demonstrates that the peptide bxyPenetratin (bxyWP) non‐covalently binds to the anti‐vascular endothelial growth factor (VEGF) protein aflibercept via hydrophobic interactions, enabling noninvasive delivery of aflibercept to the choroid and retina through conjunctival‐scleral pathway and effective inhibition of choroidal neovascularization in cynomolgus monkeys. This evidence concerns the gene VEGFA and choroidal neovascularization.