KMT2A and hereditary clear cell renal cell carcinoma: When the transcriptional complex function of KMT2A is inhibited by mm102 in fibrotic fibroblasts, the changes in H3K4me3 modification are enriched in pathways related to aberrant transcription of oncogenes, genes associated with renal cell carcinoma, breast cancer and basal cell carcinoma (Figure 5G,H).