LEGENDplexTM results indicate that systemic OPG levels are increased in COVID‐19 patients compared to HD (18.3 ng/mL vs. 6.8 ng/mL, p < 0.0001) (Figure 2A); among them, severe cases display higher OPG levels (severe 23.4 ng/mL) than mild or moderate cases (9.2 ng/mL, p < 0.0001; 13.7 ng/mL, p < 0.01) (Figure 2B), and moderate cases have higher levels than mild cases (p < 0.05). Here, TNFRSF11B is linked to COVID-19.