To better characterise the role of LDH‐A in promoting melanoma progression in male individuals and to confirm the efficacy of the pharmacological inhibition of LDH‐A in restoring an immunocompetent tumour environment in a sex‐dependent manner, we took advantage of a syngeneic murine model to establish a melanoma tumour in female and male animals. The gene discussed is LDHA; the disease is melanoma.