Although agmatine has been reported to induce HIF‐1α in neuronal cell lines in an in vitro model of Parkinson's disease (PD),49 our results show that pretreatment of LPS‐stimulated microglia with agmatine decreased HIF‐1α levels and efficiently reduced its downstream targets Slc2a1 and Pfkfb3. This evidence concerns the gene HIF1A and Parkinson disease.