MAPT and metabolic disease: Consumption of green tea and EGCG has been considered beneficial for health, mainly attributed to its antioxidant properties in treating cancer, inflammation, metabolic diseases, and cardiovascular and neurodegenerative disorders, such as Parkinson's and Alzheimer's.[291, 292] In an in vitro study to assess EGCG's efficacy, the results showed the first evidence that it selectively enhances the degradation of hyperphosphorylated tau species in rat primary culture neurons with no adverse effect on cell viability.