MAPT and Alzheimer disease: Intracellular tau aggregates are toxic to various cellular processes.[84] Likewise, accumulated evidence indicates the importance of tau aggregates in the onset of AD, including the correlation of NFTs with the progression of the disease,[85] the tau aggregates spreading AD pathology,[86] and the failure of Aβ‐targeting therapies.[87] This leads to the hypothesis that preventing aggregate formation, promoting the clearance of tau aggregates, or stabilizing microtubules would be positive in treating these disorders.