Notably, the inhibitory effect of asiatic acid on tau hyperphosphorylation was abolished upon administration of LY294002, a specific PI3K inhibitor, suggesting that asiatic acid attenuates Aβ25–35‐induced hyperphosphorylation of tau protein through the regulation of the P13K/Akt/GSK‐3β signaling pathway.[159] Additionally, Wistar rats were administered with AlCl3 and exhibited high levels of tau phosphorylation, leading to neuronal loss, cognitive decline, and high expression of CDK5 in the hippocampus and cortex. The gene discussed is MAPT; the disease is Mental deterioration.