MAPT and Alzheimer disease: Their pharmacological effects are related to treating dementia through the regulation of synaptic plasticity and the cholinergic system.[288] Red ginseng ethanolic extract and saponins inhibited tau K18 aggregation and promoted the dissociation of tau aggregates elucidated through ThT fluorescence assays.[289] In another study, the intraperitoneal administration of polysaccharide‐rich fraction obtained from red ginseng to 3×Tg‐AD mice showed ameliorated deposition and hyperphosphorylation of tau in the brain, also mitigated neurodegeneration and neuroinflammation in the mice.