MAPT and tauopathy: Consequently, research efforts have focused on active and passive immunization against tau.[57, 58] A study on the effects of active immunization on P301L tangle model mice suggests a potential delay in tauopathy progression, particularly beneficial in its early stages.[59] Likewise, passive immunization using the PHF1 antibody on homozygous female JNPL3 mice showed a reduction in tauopathy without apparent adverse effects.