These stresses could activate signaling pathways altering the gene expression, protein function, and cellular behavior.[18] Investigating RhoA and Rac1 expression and activity under mechanical strain in CRC tissue samples offers valuable insights into cancer progression.[19] This research could identify novel biomarkers for disease progression and therapeutic targets, with potential strategies focusing on modulating RhoA and Rac1 activity to disrupt cancer cell dissemination and improve patient outcomes. This evidence concerns the gene RHOA and colorectal carcinoma.