HMGCS2 and diabetes mellitus: Notably, in both the sciatic nerves of cKO mice and SCs treated with CB1R/Hmgcs2 siRNA, blocking aberrant ketogenesis restored acetyl‐CoA to levels higher than those in naïve mice/SCs, which is consistent with the aforementioned observation of robust catabolic activity in the sciatic nerve following DM (Figure 1G,H).