IL‐17 mainly stimulates fibroblasts by binding to its receptor, which promotes the expression of more pro‐inflammatory cytokines and one of them is RANKL, which activates osteoclasts and thus promotes bone erosion [61, 62, 63, 64], a frequent and common characteristic in both periodontitis and peri‐implantitis. The gene discussed is TNFSF11; the disease is periodontitis.