PRDX6 is a trifunctional enzyme with peroxidase, PLA2, and LPCAT activities.[10a] To determine whether PRDX6 promotes ovarian cancer progression via its enzymatic activities, we generated an enzymatically dead mutant of PRDX6 (C47S/S32A/D31A, namely PRDX6‐MUT), with all three enzymatic activities abrogated (Figure2A; Figure S3A,B, Supporting Information).[10, 12, 14] Wild‐type PRDX6 (PRDX6‐WT) or PRDX6‐MUT was reconstituted approximately equal to physiological level into PRDX6 KO cells (Figure 2B). This evidence concerns the gene PRDX6 and ovarian carcinoma.