PRDX6 and lung cancer: For example, the natural product thiacremonone was reported to bind PRDX6 to suppress its peroxidase activity, resulting in growth inhibition of lung cancer cells.[22] Withangulatin A, another natural small molecule, was characterized as a covalent PRDX6 inhibitor to exhibit anticancer activity against non‐small cell lung cancer by binding and inhibiting PRDX6's peroxidase and PLA2 activities.[15] However, the nonenzymatic function of PRDX6 may compromise the anticancer effects or confer resistance of these PRDX6 inhibitors specifically targeting its enzymatic activities.