NFE2L2 and lung cancer: Long‐term intake of antioxidants, like N‐acetylcysteine and vitamin E, stimulates metastasis through the reduced levels of free heme and the stabilization of BACH1 in lung cancer and melanoma.[39, 253] Elevated BACH1 levels are associated with the spread of lung cancer and reduced survival duration in individuals diagnosed with this disease.[31] An additional research investigation highlighted that promoting NRF2 activity leads to increased lung cancer spread through the inhibition of BACH1 degradation.