M1 macrophages promote beneficial immune response via pro‐inflammatory cytokines, while M2 macrophages regulate immunity and predominantly support tumor growth.[178] Studies have revealed that LINC00665 works in conjunction with BACH1 to trigger WNT1 activation, thereby influencing the M2 polarization of tumor‐associated macrophages in gastric cancer.[179] Conversely, there are contradictory findings on the role of BACH1 in macrophage polarization. The gene discussed is BACH1; the disease is gastric cancer.