It is demonstrated that metformin inhibits papillary thyroid cancer cell growth by regulating cellular energy metabolism and increasing sensitivity through the depletion of BACH1.[261] Researchers used the BACH1 inhibitor hemin and the mitochondrial function inhibitor berberine derivative (BD), to prepare nanoparticles (BH NPs). The gene discussed is BACH1; the disease is thyroid gland papillary carcinoma.