Acute leukemia has an acute onset and rapid progression, mainly including acute lymphoblastic leukemia (ALL) and acute myeloid leukemia (AML).[444, 445] Researchers develop an integrated approach for gene expression profiling to uncover better predictors of clinical behavior in ALL, and reveal BACH1 as ALL low‐risk markers.[446] It seems that BACH1 plays the role of a protector in leukemia. This evidence concerns the gene BACH1 and acute lymphoblastic leukemia.