Modulating the metabolic and oxidative stress responses to palmitate, contributing to the dysfunction of human pancreatic β‐cellsHepatocyte‐specific BACH1 deficiency elevates insulin signaling and alleviates abnormal glucose homeostasis regulation in high‐fat diet (HFD)‐caused hepatic insulin resistance, and finally prevents individuals from HFD‐induced steatosis. Here, INS is linked to Insulin resistance.