Tumor cells commonly exhibit heightened aerobic glycolysis and generate lactic acid as their primary metabolic alterations.[258, 259] BACH1 and glycolytic gene expression have been shown to be positively correlated in lung cancer.[39] BACH1 triggers the transcription of hexokinase 2 (HK2) and Glyceraldehyde‐3‐phosphate dehydrogenase (GADPH), leading to enhanced absorption of glucose, acceleration of glycolysis, and release of lactate, thereby driving glycolysis‐dependent metastasis in both mouse and human lung cancer cells. The gene discussed is BACH1; the disease is neoplasm.