HK2 and neoplasm: Tumor cells commonly exhibit heightened aerobic glycolysis and generate lactic acid as their primary metabolic alterations.[258, 259] BACH1 and glycolytic gene expression have been shown to be positively correlated in lung cancer.[39] BACH1 triggers the transcription of hexokinase 2 (HK2) and Glyceraldehyde‐3‐phosphate dehydrogenase (GADPH), leading to enhanced absorption of glucose, acceleration of glycolysis, and release of lactate, thereby driving glycolysis‐dependent metastasis in both mouse and human lung cancer cells.