Meanwhile, BACH1 is inactivated and dissociates from DNA under oxidative stress.[83] BACH1 antagonizes the actions of NRF2, leading to increased ROS production in cancer and neurodegenerative diseases, suppression of angiogenesis in ischemic cardiovascular disease, and facilitation of cellular senescence and apoptosis in many diseases. The gene discussed is NFE2L2; the disease is neurodegenerative disease.